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Areas of Research

The Barrett's Esophagus Research Group performs clinical, translational, and basic science research investigating the origins of Barrett's esophagus (BE) and its progression to esophageal adenocarcinoma (EAC).  Areas of research include:

-Development of a transgenic mouse model of BE and EAC
-Organotypic models of BE and EAC
-Stem cells and the origins of BE
-Notch signaling in the development of BE and progression to EAC
-The role of gastrin in BE and EAC
-Novel chemopreventive agents for BE
-Identification of novel biomarkers that predict neoplastic progression, response to endoscopic therapy, and recurrence after ablative therapy

For patients:

We have several ongoing studies at Columbia, the University of Pennsylvania, and the Mayo Clinic, including:

 

·         Identifying markers of cancer risk

·         Trials of different treatments for Barrett's esophagus, including radiofrequency ablation and cryoablation therapy

·         Drug studies aimed at preventing esophageal cancer in Barrett's esophagus patients