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Research Projects

The goal of our consortium’s research is to generate a clear understanding of the mechanisms underlying the development of Barrett’s esophagus and EAC, and subsequently to transform this knowledge into clinical practice that will improve patient outcomes and decrease the disease burden of EAC. Our novel preclinical models serve as the foundation for testing these hypotheses, which are then brought ultimately to the clinical arena in a true translational, “bench-to-bedside” approach through biomarker and chemoprevention studies.


Our research is divided into three broad areas and involves numerous basic, translational, and clinical studies:


Project 1: Role of Notch Signaling in Novel Models of Barrett’s Esophagus


Project 2:  Identification of the Cell of Origin in Barrett’s Esophagus


Project 3:  Identification of Novel Biomarkers and Gene Signatures in Barrett’s Esophagus